Physician Formulated Ophthalmic Complex

INTESSA

NMN Eye Health Formula

Developed by Dr. Anthony Curreri, MD — a board-certified ophthalmologist — for patients who deserve every evidence-supported tool available for their eyes.

Where to Buy Intessa View the research
500mgNMN per capsule
5Active mechanisms
3Active clinical trials
30Day supply
Physician Formulated
500mg NMN
AREDS2-Matched Doses
GMP Certified
FDA Registered Facility
100% Vegan
INTESSA
Physician Formulated · Ophthalmic Complex
Advanced Ocular Longevity Formula*
NAD+ · Macular Protection · Optic Nerve Support*
Activated Absorption — Piperine*
30 Capsules · 1 Daily

The Formula

Five mechanisms.
One daily capsule.

Intessa was formulated to address every major pathway implicated in age-related ocular disease — in a single, bioavailable capsule you take once a day.

NMN (Nicotinamide Mononucleotide)500mg
Lutein (from Marigold)10mg
Zeaxanthin (from Marigold)2mg
Vitamin B6 (P5P) + B12 (Methylcobalamin)10mg + 1mcg
Black Pepper Extract (95% Piperine)10mg
Learn More About the Formula

Why Intessa

Targeting the mechanisms
that matter most

01

NAD+ Replenishment

NAD+ declines 40–50% by age 60. Retinal ganglion cells and photoreceptors have the highest NAD+ demand of any tissue. 500mg NMN bypasses the rate-limiting NAMPT enzyme to restore NAD+ directly.

02

Macular Protection

Lutein 10mg and Zeaxanthin 2mg — the exact doses from the landmark AREDS2 trial — concentrate in the macula to filter blue light and neutralise reactive oxygen species in the photoreceptors.

03

Optic Nerve Support

Pyridoxal-5-Phosphate and Methylcobalamin in their bioactive forms support one-carbon metabolism and optic nerve axon integrity — validated by the Karolinska Institute's 2025 glaucoma research.

04

Activated Absorption

95% Piperine extract inhibits intestinal enzymes and P-glycoprotein efflux, increasing absorption of every co-ingredient by up to 30–60%. Every dose delivers its full clinical value.

05

Physician Formulated

Designed by Dr. Anthony Curreri, MD — a board-certified ophthalmologist. Not a general wellness supplement. Formulated specifically for the metabolic vulnerabilities that drive ocular ageing.

06

One Daily Capsule

Five mechanisms. One capsule. Patients buying equivalent coverage separately would need three or more products. Intessa delivers everything together, once a day.

Dr. Anthony Curreri, MD — Board-Certified Ophthalmologist

The Physician Behind the Formula

Dr. Anthony
Curreri, MD

Board-Certified Ophthalmologist · New York City

Dr. Curreri has spent his career studying the metabolic vulnerabilities that make the ageing eye susceptible to glaucoma and macular degeneration. What he found in the published literature — and what he saw in his own patients — led him to formulate Intessa.

"The research is clear. Your eyes need NAD+. I formulated Intessa to deliver it."

Board-Certified Ophthalmologist
Specialising in glaucoma and retinal disease
161 East 32nd Street, New York, NY 10016

The Clinical Evidence

Built on published,
peer-reviewed research

Every ingredient in Intessa is supported by published clinical evidence. This is not a general wellness supplement — it is a targeted ophthalmic formula grounded in the latest ocular science.

JAMA Ophthalmology

2022 · Columbia University

NAD+ precursor supplementation improved visual field function in open-angle glaucoma patients

Phase 2 RCT. Patients on stable IOP-lowering therapy showed statistically significant improvement in retinal ganglion cell function after NAD+ supplementation vs. placebo.

De Moraes et al. · Columbia University Irving Medical Center

Cell Reports Medicine

2025 · Karolinska Institute

B vitamin supplementation halted optic nerve damage without reducing eye pressure

Dysregulated one-carbon metabolism confirmed in human glaucoma tissue. B6 and B12 completely halted axon degeneration in validated animal models.

Tribble et al. · Karolinska Institute / UCL

Cell Reports

2016 · Washington University

NMN administration rescued photoreceptors from retinal degeneration

Deletion of the NMN biosynthesis enzyme NAMPT caused rapid retinal degeneration. Daily NMN completely rescued photoreceptor structure and visual function.

Lin et al. · Washington University School of Medicine

JAMA Ophthalmology

2013 · National Eye Institute

Lutein 10mg + Zeaxanthin 2mg reduced AMD progression risk

The landmark AREDS2 multi-centre RCT. The exact lutein and zeaxanthin doses used in Intessa are the most rigorously validated macular protection doses in ophthalmic history.

AREDS2 Research Group · National Eye Institute

Journal of Glaucoma

2017 · Jackson Lab / Karolinska

NAD+ replenishment protected ~70% of eyes from glaucomatous neurodegeneration

The foundational study establishing glaucoma as a NAD+-sensitive metabolic optic neuropathy. Protection was independent of intraocular pressure reduction.

Williams et al. · Jackson Laboratory / Karolinska Institute

Active Clinical Trials

2024–2027 · Three Centres

Three Phase 2/3 trials currently testing NAD+ precursors in glaucoma patients

NCT05405868 (Moorfields/UCL), NCT05695027 (Columbia), NCT06991712 (Hong Kong — testing NMN directly at 350mg in POAG patients). The clinical consensus is forming.

Intessa was formulated ahead of this emerging consensus.

Where to Buy

Find Intessa
near you

Intessa is currently available at Dr. Curreri's ophthalmology practice in New York City. Enter your zip code below to find your nearest location.

✦ Nearest location
Dr. Anthony Curreri, MD — Ophthalmology
161 East 32nd Street, New York, NY 10016
(212) 979-2020
Get Directions Call the Office

More locations coming soon as Intessa expands to physician partners nationwide.

Ask Your Doctor

Your eyes deserve
every advantage.

Ask Dr. Curreri about Intessa at your next appointment, or call the office to learn more.

Call (212) 979-2020